January 8, 2022 By Alexa Mangolia 0

Percocet vs. Vicodin: Differences, similarities, and which is better for you

Percocet vs. Vicodin: 

Percocet and Vicodin belong to the brand names of different medications. Percocet is available as both a brand name and generic form, and Vicodin is only available as a generic form; therefore, they both work and act similarly. Percocet vs.Vicodin are sedative medications, Vicodin contains the opioid hydrocodone, and Percocet contains the opioid oxycodone.

Vicodin and Percocet are both prescribed medication to treat moderate to severe pain, and for most of the part, they should only be recommended to cure acute or short-term pain caused/occur by an injury or surgery; However, In a few cases, these medications may be described to treat chronic or long term pain due to conditions such as cancer.

Percocet is a prescription medication usually used to help relieve moderate to severe pain; therefore, It contains a combination of acetaminophen and oxycodone; therefore, Vicodin is a drug containing acetaminophen hydrocodone, a semi-synthetic opioid that binds sedative receptors to provide relief from moderate to severe pain.

Although these two medications differ in their opioid composition, previous studies have shown that Percocet and Vicodin treat pain equally, Percocet and Vicodin have similar half-lives of approximately 4 hours, and both medications are used to cure the acute pain and can be expected to provide pain relief for anywhere between 4 to 6 hours.

Differentiation between Percocet vs Vicodin

Both drugs are highly effective in treating pain. In a study comparing the medications, researchers found that they worked equally well for short-term pain management; another study showed they worked equally well in treating acute pain caused by fractures.

However, a specific study found that oxycodone, the drug in Percocet, was 1.5 times more potent/powerful than hydrocodone, the drug in Vicodin when prescribed and taken at equal doses. The primary difference between these two drugs is that Percocet contains the opioid oxycodone while Vicodin contains the opioid hydrocodone; therefore, they also include acetaminophen and acetaminophen amounts in Percocet or Vicodin varies depending on the formula.

Aside from the similarity of these medications in treating pain, there are some differences between these two medications; Percocet is more likely than Vicodin to cause nausea, dizziness, drowsiness, fatigue, and headaches. Some studies show that people using Vicodin experience constipation and stomach pain more frequently than people who take Percocet.

Which is more effective between Percocet and Vicodin?

Both of these opioid pain relievers work in the same general way-the directly affect the central nervous system, interfering with pain signals sent from other parts of the body. Many healthcare pharmacists prescribe Percocet in the case of severe pain-related issues. Again, both medications are effective, but Percocet is likely more potent than Vicodin.

According to the studies, Percocet is more potent than Vicodin. As in generally the case with more powerful opioids, there is a higher risk of abuse associated with the use of Percocet. Percocet and Vicodin are prescribed for the short-term treatment of pain and should only be taken in the manner described by your doctor.

Side effects of Percocet and Vicodin

Vicodin and Percocet are combinations of a narcotic and non-narcotic pain reliever used for the relief of moderate to severe pain, and along with its needed effects, various side effects can occur with Percocet and Vicodin thus, they both are opioid medications, so they share similar side effects which are as mentioned below:

  • Lightheadedness
  • Dizziness
  • Anxiety
  • Nausea
  • Vomiting
  • Upset stomach
  • Mood changes
  • Blurred vision.
  • Constipation
  • nausea
  • drowsiness
  • Dizziness
  • itching
  • dry mouth

A severe life-threatening serotonin syndrome could occur with Percocet and Vicodin, especially when taken with other drugs that increase serotonin.

Severe not less common side effects can occur with Vicodin and Percocet medications, and if you have any of these side effects, call your doctor immediately; these side effects may include:

  • Trouble breathing
  • Seizures
  • Low blood pressure
  • Rapid heartbeat
  • Painful urination or trouble urinating
  • Allergic reactions will occur, such as itching, hives, trouble breathing, or swelling of your tongue or throat.

Which is better between Percocet and Vicodin

Percocet and Vicodin should only be used short-term unless given for unremitting cancer-related pain. Vicodin, Percocet, and other similar opioid-type pain-relieving tablets should not be used long-term for chronic non -cancer-related pain relief.

According to the studies, Percocet is more potent than Vicodin. This is usually the case for the more potent opioids; there is a higher risk of abuse associated with Percocet and.

Percocet and Vicodin are considered for the short-term treatment of pain and should only be taken in the manner described by your doctor.


Percocet and Vicodin are potent opioids, and they treat moderate to severe pain, such as that following an accident or surgery. Percocet is accessible in both a generic unbranded form; the brand name form of Vicodin has been discontinued; however, it is only accessible as a generic.

Like other sedatives, both Vicodin and Percocet pose a high risk of addiction. To avoid this, only take an opioid according to the doctor’s instructions and visit the doctor for routine monitoring. Both can cause serious side effects and interact with other medication, supplements, and recreational drugs, including alcohol.


Q-Is Percocet or Vicodin better?

A- Both drugs seem to be similarly effective, as seen in the studies described above. If you have severe, acute pain that is not controlled with a non-opioid medication, your doctor may recommend trying Percocet or Vicodin on a short-term basis. Consult your healthcare provider for more information.

Q- Is Percocet an opiate or opioid?

Often, we see these terms used interchangeably, but they are not precisely the same.

An opiate is a drug that comes from opium, as in the poppy plant. An opioid can be natural or synthetic, and Percocet is an opioid—it is synthetic and not found naturally in opium.

Q- is oxycodone the same as Percocet?

A- oxycodone is the same opioid as Percocet, oxycodone, and Endocet. Both Percocet and oxycontin relieve pain, but while Percocet relieves for about five hours, the effects of oxycontin last for about 12 hours.

Q-what is the difference between Percocet and Vicodin.

A- percent is more likely to be abused because it contains oxycodone which appears to have a higher abuse liability potential than hydrocodone contained in Vicodin. They are combinations of pain-relieving tablets; both contain acetaminophen and an opioid-type ingredient. The opioid in Vicodin is hydrocodone, and the opioid is Percocet vs. oxycodone.

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